Tina Huang is a data scientist currently working at a large FAANG enterprise. She has been working for the data sciences industry since 2014. In product development, 80% of the success of a product is determined by 20% of its features. Proc. The ancestry found in individuals associated with the preceding Aurignacian culture from central Europe (GoyetQ116-1ancestry) gave rise to Gravettian-associated individuals from western and southwestern Europe. Tina has an MSc in Computer Science from the University of Pennsylvania, and an HBSc in Pharmacology from the University of Toronto. At this startup dedicated to b2b marketing, we, the data team formed by 2 people, are organizing all the data from zero and looking for their real value. Basically, you minimize effort and maximize outcomes. 803147-RESOLUTION (to S.T. Its no surprise that she was selected for the Code Cup, a yearly event where students from all over the world compete in coding challenges. ), no. Natl Acad. In this debated framework, Gravettian-associated individuals have been suggested to represent a biologically homogeneous population on the basis of craniometric and genomic data4,22. How to Rock at Data Science with Tina Huang, Older: Daily Habit #8: Math or Computer Science Exercise . All individuals belonging to the Fournol cluster show higher affinity to Goyet Q116-1 than to the Sunghir group (n=4), and the Vstonice-cluster individuals show higher affinity to the Sunghir group than to Goyet Q116-1 (Extended Data Fig. . Gonzlez-Fortes, G. et al. Li, H. et al. The LGM could thus have created a corridor south of the Alps for east-to-west human movements that genetically connected hunter-gatherer populations from the Balkans to Iberia, possibly also via dispersals along existing lower-sea-level coasts32. A.G.-O. Commun. Despite this wide geographical range, it is not clear whether different groups associated with this culture originated from a common source population and how those groups were genetically related to each other. "At that time, hunter-gatherers with distinct ancestries and appearances started to mix with each other. Article The suspension was then centrifuged and transferred into a binding buffer as previously described56. 6 and Supplementary Fig. Genome Biol. Sci. If material is not included in the articles Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. Karmin, M. et al. DNA analysis of an early modern human from Tianyuan Cave, China. CONTACT US Contact us. Quat. . And if youre new to data science, check out the 365 Intro to Data and Data Science course. Curr. Mittnik, A. et al. Furthermore, the gene pool of the western Gravettian populations is found continuously for at least 20,000 years: their descendants who are associated with the Solutrean and Magdalenian cultures stayed in southwestern Europe during the coldest period of the last Ice Age (between 25,000 and 19,000 years ago) and later spread north-eastward to the rest of Europe. The PCA was calculated with 1379 individuals from 87 western Eurasian modern populations on the 1240k_HO dataset, which was intersected between the 1240k and Human Origins datasets (Supplementary Data 1.K). The membrane was able to achieve FRR of 98.73 0.83 % after 4 cycles of filtration, indicating that anti-fouling properties have been enhanced. Max Planck Institute for Evolutionary Anthropology. "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. Genome sequence of a 45,000-year-old modern human from western Siberia. Article In spite of growing discussions about its nature27,28, the Epigravettian culture has been traditionally assumed to be the result of a transition from the preceding local Gravettian29. Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Upper Palaeolithic genomes reveal deep roots of modern Eurasians. The newly defined Fournol cluster is closely related to Aurignacian-associated individuals from Belgium dated to 35ka (Goyet Q116-1 and the newly reported Goyet Q376-3 individual). Hajdinjak, M. et al. Details on individuals involved in the analysis, read counts processing and allele frequency computation are provided in the Supplementary Information, section12 and Supplementary Data 1.J and 3.G. After the LGM, the Epigravettian culture was widespread in southern andsoutheastern Europe. This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. In the box plot the centre line is the median, box bounds delineate the interquartile range and whiskers extend to maximum and minimum values, excluding outliers. Dr. Huang received her BS degree in Chemistry from Bethel College and her PhD in Analytical Chemistry from the University of Kansas in 1998. Extended Data Fig. Nature 528, 499503 (2015). My experience includes an [] The course is well structured and just what one needs before preparing for a data science interview with focus on SQL. Tina Huang hellotinah@gmail.com | 123-456-7890 | 1 BeepbeepBoop St. Philadelphia, PA 19104 EDUCATION AND HONORS University of Preistoria e Antropologia, Universit degli Studi di Siena, Siena, Italy, Stefano Ricci,Francesco Boschin&Annamaria Ronchitelli, Centro Studi sul Quaternario ODV, Sansepolcro, Italy, Institut National de Recherches Archologiques, Bertrange, Luxembourg, Department of Cultural Heritage, University of Bologna, Ravenna, Italy, Gregorio Oxilia,Eugenio Bortolini,Stefano Benazzi&Matteo Romandini, Human Ecology and Archaeology (HUMANE), Department of Archaeology and Anthropology, Instituci Mil i Fontanals de Investigacin en Humanidades, Consejo Superior de Investigaciones Cientficas (IMF - CSIC), Barcelona, Spain, UMR 7209Archozoologie et Archobotanique-Socits, Pratiques et Environnements, Musum National dHistoire Naturelle, Paris, France, Dipartimento di Scienze Della Vita e DellAmbiente, Sezione di Neuroscienze e Antropologia, Universit Degli Studi di Cagliari, Cittadella Monserrato, Cagliari, Italy, Dipartimento di Civilt e Forme Del Sapere, Universit di Pisa, Pisa, Italy, Center for Isotope Research, Groningen University, Groningen, The Netherlands, UMR 7206 co-Anthropologie, quipe ABBA. under exclusive license to Springer Nature Singapore Pte Ltd. 2022 R. Huang et al. As a general rule of thumb, we start from the simplest issue and gradually increase in complexity. Big data data warehousing and data science are two sub-tasks of a larger endeavor called data science, which is a sub-tasks of data science. We looked at data on how many people had been dropped, the time when they were dropped, and the time they were found. In panel b, the colour code does not imply archaeological similarities. We can have either structured data (e.g. Genetic ancestry changes in Stone to Bronze Age transition in the East European plain. Resurrected Supernova Provides Missing-Link, Bald Eagles Aren't Fledging as Many Chicks, Ultracool Dwarf Binary Stars Break Records, Deflecting Asteroids to Protect Planet Earth, Quantum Chemistry: Molecules Caught Tunneling, Shark from Jurassic Period Highly Evolved, 2.9-Million-Year-Old Butchery Site Reopens Case of Who Made First Stone Tools, Gut Microbes Can Boost the Motivation to Exercise, Warmer Climate May Drive Fungi to Be More Dangerous to Our Health, Seawater Split to Produce 'Green' Hydrogen. Ontario Institute for Cancer Research Toronto, ON. 2a). We also compared its affinity to El Mirn (northern Spain), the oldest Magdalenian-associated individual sequenced to date (19ka). Surprisingly, the research team found that populations from different regions associated with the Gravettian culture, which was widespread across the European continent between 32,000 and 24,000 years ago, were not closely related to each other. & Dolukhanov, P.) 122145 (Avebury, 1993). Sep 2017 - Aug 20181 year. In no time, she established herself as one of the favorite vloggers of the data community. Google Scholar. After merging, individuals with less than 6,000 SNPs on 1240k sites were excluded from further analysis because of low coverage. As previously hinted37, we find a large frequency variation in alleles related to skin and eye pigmentation among post-LGM hunter-gatherer groups. Corporate Financial Managementspring term (BS 2508) Second year of undergraduate. "Presumably, these people came from the Balkans, arrived first in northern Italy around the time of the glacial maximum and spread all the way south to Sicily.". Ongoing symptoms 3 months after infection by SARS-CoV-2 are well described as long COVID and have become a global health concern [1], [2].Fatigue and dyspnea are the two most common symptoms after infection by SARS-CoV-2 and low physical performance impacting daily activities has been described for up to 6 months after infection [3]. Fifth, the Oberkassel ancestry in western and central Europe and the Sidelkino ancestry in eastern Europe remained largely isolated for almost 6,000 years until genetic interactions were first observedaround 8ka in northeastern Germany, possibly associated with cultural exchanges along the Baltics49 and around 7.5ka in the upper Volga region, possibly linked to the spread of pottery in the region50. The detailed grouping of individuals shown with empty coloured circles is described in Supplementary Data 1.I. 15, 193223 (2005). Ecol. 4). The team analysed the genomes of 356 prehistoric hunter gatherers from different archaeological cultures -- including new data sets of 116 individuals from 14 different European and Central Asian countries. View Tina Huang's profile on LinkedIn, the world's largest professional community. The population history of northeastern Siberia since the Pleistocene. The x-axes report the geographic regions as divided in Fig. Her first stepping stone into data science was being a research assistant in Bioinformatics. Radiocarbon 55, 163177 (2013). As of right now, it doesnt seem that MySQL is the right choice for storing data because the database is so large, it would be impossible to find and query the necessary information. PLoS Genet. Quat. Curr. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. eLife 11, e77625 (2022). Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. First, we show that individuals associated with the Gravettian culture across Europe were not a biologically homogeneous population. Google Scholar. In product development, we do lots of opportunity sizing to decide which features to build and what opportunities to invest in. Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. - Technical researcher and data analyst under the supervision of Dr. A. Meyer and Dr. S. Bae at UCLA. In this admixture graph, the lineage related to Zlat k splits more basally than the Bacho Kiro IUP group, who contributes to Tianyuan, UstIshim and Goyet Q116-1 (indicated with red lines), but not to the Sunghir group. Tina Huang. 1c). The mapped reads from the same individual and library set-up were merged and duplications were removed with DeDup. Present-day individuals (gray dots) genotyped on theHumanOrigins dataset are used to define the PCA variation onto which ancient genomes (coloured symbols) are projected. Then we combined our newly generated genotypes with published genotypes from ancient and modern individuals from AADR v42.4 (Allen Ancient DNA Resource (https://reich.hms.harvard.edu/allen-ancient-dna-resource-aadr-downloadable-genotypes-present-day-and-ancient-dna-data) version 42.4) for downstream analysis1,4,7,14,16,23,36,37,38,39,40,42,43,45,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94. The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. Nature 615, 117126 (2023). For individual heterozygosity calculation, we also called pseudo-diploid genotypes from each library, using pileupCaller 1.4.0.3 under random diploid calling mode and the same strategy for different types of libraries as pseudo-haploid genotype calling. Evol. Google Scholar. J. & Posth, C. Latest trends in archaeogenetic research of west Eurasians. Nat. Definitely a course worth investing in as it sticks out as a unique course focusing on SQL interviews and doesn't contribute to the abundance of generic courses on the internet! Notably, this genetic distinction coincides with dissimilarities in mortuary practice among genetically analysed Gravettian-associated individuals from different parts of Europe. By using our site you agree toour Floor Coatings. Freshwater radiocarbon reservoir effects at the burial ground of Minino, Northwest Russia. The length of the colour bar shows the proportion of each ancestry. Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. It can take several minutes for a query to complete, and if youre using a lot of data the whole table may be locked up. Mathieson, I. et al. This is one of the things that make us stand out from other platforms which usually consider mathematics and statistics a prerequisite. Tina Huang. We use cookies to improve your experience and give you personalized content. Max Planck Institute for Evolutionary Anthropology. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. Learn with a sense of purpose. Commun. Lcuyer, C., Hillaire-Marcel, C., Burke, A., Julien, M. A. Many students or recent graduates appreciate her for sharing what helped her break into the field. Substantially contaminated libraries as well as marginally contaminated libraries of individually analysed genomes were filtered to maintain reads showing postmortem DNA damage (Methods and Supplementary Figs. Highly Influential Citations 3. Piezonka, H. et al. Second, the ancestry of individuals associated with the Epigravettian culture (Villabruna cluster), which was found to genetically connect European and Near Eastern hunter-gatherers, reached southern Europe well before the transition between the Early and Late Epigravettian4,15 and possibly as early as the GravettianEpigravettian transition. University Universit Chouaib Doukkali; . These authors contributed equally: Cosimo Posth, He Yu, Archaeo- and Palaeogenetics, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tbingen, Tbingen, Germany, Cosimo Posth,Dorothe G. Drucker,Herv Bocherens,Christoph Wiing,Nicholas J. Conard&Katerina Harvati, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, Cosimo Posth,He Yu,Ayshin Ghalichi,Hlne Rougier,Yilei Huang,Harald Ringbauer,Adam B. Rohrlach,Kathrin Ngele,Vanessa Villalba-Mouco,Rita Radzeviciute,Tiago Ferraz,Alexander Stoessel,Rezeda Tukhbatova,Wolfgang Haak&Johannes Krause, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China, Department of Anthropology, California State University Northridge, Northridge, CA, USA, Universit de Bordeaux, CNRS, MC, PACEA UMR 5199, Pessac, France, Isabelle Crevecoeur,Andr Morala,Stphane Madelaine,Priscilla Bayle,Bruno Maureille,Jean-Guillaume Bordes&Mona Le Luyer, School of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia, Instituto Universitario de Investigacin en Ciencias Ambientales de Aragn, IUCA-Aragosaurus, Zaragoza, Spain, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany, Institute of Zoology and Evolutionary Research, University of Jena, Jena, Germany, Center of Excellence Archaeometry, Kazan Federal University, Kazan, Russia, Department of Biology, University of Florence, Florence, Italy, Martina Lari,Alessandra Modi&Stefania Vai, Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia, Tina Saupe,Christiana L. Scheib&Luca Pagani, St Johns College, University of Cambridge, Cambridge, UK, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy, Department of Biology, University of Padova, Padova, Italy, Department of Chemistry G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, UMR 8068 CNRS, TEMPSTechnologie et Ethnologie des Mondes Prhistoriques, Nanterre Cedex, France, Laurent Klaric,Olivier Bignon-Lau,Grgory Debout,Michel Orliac,Pierre Bodu,Bndicte Souffi&Frdrique Valentin, Muse National de Prhistoire, Les Eyzies de Tayac, France, UMR 5140 CNRS, Archologie des Socits Mditerranennes, Universit Paul-Valry, Montpellier, France, UMR 7194, Histoire Naturelle de lHomme Prhistorique (HNHP), Dpartement Homme et Environnement, Musum National dHistoire Naturelle, CNRS, UPVD, Paris, France, Association APRAGE (Approches pluridisciplinaires de recherche archologique du Grand-Est), Besanon, France, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK, Dipartimento di Scienze Fisiche, della Terra e dellAmbiente, U.R. Search 210,843,632 papers from all fields of science. Hi! This suggests a very small recent effective population size, estimated to be in the order of around 70 individuals (Supplementary Table 2), causing the low genetic diversity in Sicilian Epigravettian hunter-gatherers. An early modern human from Romania with a recent Neanderthal ancestor. Theyre both important sub-tasks for data scientists to master, but big data data warehousing and data science are only two components of the larger data science endeavor. @hellotinah. Large-scale genomic analysis documents the migrations of Ice Age hunter-gatherers over a period of 30,000 years -- they took shelter in Western Europe but died out on the . Nature thanks Marta Mirazn Lahr, Ludovic Orlando and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Curr. 26, 827833 (2016). Biol. c, MDS plot of European hunter-gatherers based on 1f3(Mbuti; pop1, pop2). Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry. Within Sicily, the 14ka Oriente C individual shows higher affinity with the much younger but geographically closer 10ka Uzzo group30 (n=2) than with the almost contemporaneous San Teodoro 2 individual from eastern Sicily. Overall, the Solutrean-associated Le Piage II individual links the preceding Fournol ancestry with the succeeding ancestry found in El Mirn, providing direct evidence for genetic continuity throughout the LGM in southwestern and western Europe. Gnther, T. et al. Sci. Xiamen Guansheng Precision Machinery Co Ltd is a company integrating R&D, production and sales. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. This affinity is even stronger towards Epigravettian-associated individuals from western and central Italy and Sicily (group 2 and group 3, respectively) than to those from northern Italy (group 1) (Supplementary Data 2.F). PubMed Central PubMed Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. Contrary to West Siberian hunter-gatherers, Tutkaul 1 does not carry an extra eastern Eurasian ancestry, but shows affinity to Iranian Neolithic farmers and some younger populations from Iran and the Turan region (Supplementary Data 2.L). TV Actress. Bilateral trade between China and Russia in 2022 rose 34.3% year-on-year to a record high of 1.28 trillion yuan ($190 billion) in yuan-denominated terms, Chinese customs data showed in early January. Its also hard to predict whats going to happen, but I hope its interesting to people who want to learn more about data science. Ive always liked the idea of using data to make predictions. a, Population structure among Epigravettian-associated populations revealed by a neighbour-joining tree based on pairwise f2 genetic distances. Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. It just raised $12.2 million. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. For the DNA lysis, a solution of 900l EDTA, 75l H2O and 25l proteinase K was added. Correspondence to "Ice Age survivors." It encourages me to go out and re-learn SQL and excites me for the mock interviews to come. We give some of our best tips to improve them and hopefully help you all land a data science interview. Disease-modifying, readily available, and easily affordable medical therapies for hypertension are ubiquitous and set a high bar for any new therapeutic. Individuals and groups are plotted with the same colours and symbols as in Fig. USA 111, 22292234 (2014). 27 and 28). This is first detected in an individual from Gross Fredenwalde in northeastern Germany and reaches around 10% in most European hunter-gatherer individuals thereafter (Extended Data Fig. After the LGM, a genetic component distantly linked to the Goyet Q116-1 individual from Belgiumdated to 35 kanamed GoyetQ2 ancestry(hereafter, GoyetQ2 cluster or ancestry)reappeared in individuals from southwestern and central Europe associated with the Magdalenian culture (1914ka from Iberia to eastern Europe across central Europe) and in an admixed form in subsequent Final Palaeolithic and Mesolithic hunter-gatherers4,14, but the geographic extension of this ancestry is still unclear. 4, 324333 (2020). 9, 442 (2018). Admixture graphs were reconstructed using qpGraph 6450, with allsnps mode to correct for low-coverage sample and Mbuti.DG set as the outgroup. 2, e190 (2006). Greater San Diego Area. 27, 21852193.e6 (2017). For consistency with the previously discussed nomenclature, we rename the EHG ancestryas the Sidelkino cluster(hereafter, Sidelkino cluster or ancestry). Citations 52. Echinacea, also known as Coneflower, is legendary for a reason: science has shown multiple species of Echinacea can provide potentially broad-reaching support for the innate and adaptive immune system. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Evol. Billed once. In this study, we analyse 356 ancient hunter-gatherer genomes including new genomic data of 116 individuals dated to 355ka alongside a novel contamination-estimation method based on runs of homozygosity. The number of individuals in each group is written to the right of each bar. Gansauge, M., Aximu-Petri, A., Nagel, S. & Meyer, M. Manual and automated preparation of single-stranded DNA libraries for the sequencing of DNA from ancient biological remains and other sources of highly degraded DNA. Junior Data Scientist May 2017 - April 2018. These f4-statistics also confirm that Goyet Q376-3 carries a similar ancestry to Goyet Q116-1 and Kostenki 12 carries a similar ancestry to the Sunghir group, whereas Bacho Kiro 1653 (35ka) from Bulgaria, Muierii 1 (34ka) and Cioclovina 1 (32ka) from Romania, and Paglicci 133 (33ka) from southern Italy are equally related to Goyet Q116-1 and Sunghir.
Mattress Firm 300 Adjustable Base Remote Manual, Humiliating Nicknames, Slice Pandas Dataframe By Column Value, Old Country Bbq Pits Pecos Smoker Accessories, Girl Pusher Domestic Violence, Articles T